| Synthesis and Characterization of Therapeutic Liposomes for Radionuclide Delivery: A Targeted Approach for Moderate Joint Inflammation |
| کد مقاله : 1050-ICOC |
| نویسندگان |
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میثم اکبری1، Elham Sattarzadeh Khameneh2، Fariba Johari Deha2، leila koopaei2، Saeed Kakaei *2 1دانشجو 2Radiation Applications Research School, Nuclear Science and Technology Research Institute, Tehran, Iran |
| چکیده مقاله |
| Liposomes, as biocompatible drug carriers, have gained a prominent position in modern drug delivery systems due to their advantages such as enhanced drug stability, reduced side effects, and the ability to achieve targeted delivery [1, 2]. Liposomes are spherical vesicles ranging from several nanometers to a few micrometers in size, composed of one or more phospholipid bilayers surrounding an aqueous core [3]. Owing to their amphipathic nature, liposomes can simultaneously encapsulate and transport both hydrophilic and lipophilic therapeutic agents [4]. Figure 1 illustrates the general structure of liposomes. Furthermore, their structural similarity to biological membranes results in excellent biodegradability and low toxicity, making them highly suitable for biomedical applications [5]. These characteristics have established liposomes as a versatile and efficient platform in both diagnostic and therapeutic fields, with notable applications in conditions such as arthritis, cancer, and inflammatory diseases [6]. In this study, phospholipid-based liposomes were synthesized using the thin-film hydration technique, followed by size reduction via ultrasonic treatment. The primary goal was to produce liposomal vesicles within the 2–10 µm size range for potential use in drug delivery and inflammation reduction. Key formulation variables—including the phospholipid-to-cholesterol ratio, ultra-sonication time, and hydration temperature—were systematically investigated and optimized. The results indicated that medium-intensity ultra-sonication significantly enhanced particle-size uniformity. The proposed approach can be performed with minimal equipment and is suitable for both laboratory-scale and semi-industrial drug delivery applications. The physicochemical characteristics of the final liposomal formulation were evaluated following ultrasonic size refinement. |
| کلیدواژه ها |
| Liposome , Drug delivery, Hydration |
| وضعیت: پذیرفته شده |