| Palladium-Catalyzed Multi-step Domino Sequence of ortho-X-Allenyl Tethered Aryl Isocyanides: Access to Fused Benzazole Frameworks |
| کد مقاله : 1187-ICOC |
| نویسندگان |
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لیلا ساعی فرد *1، سعید بلالایی2، کامران امیری1 1دانشگاه صنعتی خواجه نصیرالدین طوسی 2دانشگاه صنعتی خواجه نصیر الدین طوسی |
| چکیده مقاله |
| A stereoselective palladium-catalyzed multi-step domino transformation of a newly designed class of ortho-X-allenyl tethered aryl isocyanides has been developed, providing efficient access to fused polycyclic heterocycles, including 2-substituted benzoxazoles, benzothiazoles, and benzimidazoles in moderate to good yields. The domino sequence— consisting of allene isomerization, isocyanide insertion, migratory cycloisomerization, and a final [4+2] cycloaddition— displays broad substrate scope and excellent functional-group tolerance (Scheme 1). |
| کلیدواژه ها |
| palladium catalysis, multi-step domino reaction, functionalized isocyanides, benzazole, migratory cycloisomerization |
| وضعیت: پذیرفته شده |