Trimesic acid based multicomponent reaction in NaCl solution

کد مقاله : 1190-ICOC

نویسندگان

عباس عظیمی روشن * دانشگاه پیام نور

چکیده مقاله

IMCRs are now a cornerstone of MCR chemistry, widely utilized in medicinal and synthetic chemistry. They are valued for their ability to synthesize complex molecular frameworks from simple, inexpensive starting materials due to their excellent functional group tolerance, bond-forming efficiency, and atom-, pot-, and step-economy [1-3]. In this study, Green Pseudo-Seven Component reaction and environmentally friendly process was used for the pseudo-seven component reaction between readily available Trimesic acid, isocyano-cyclohexane, and various aldehydes. This rapid method produced the tris-cyclohexylamino-oxo-benzene-1,3,5-tricarboxylates (Figure 1) in relatively acceptable and more reasonable reaction times and high achievable efficiencies by employing a Passerini reaction. NaCl solution was used as an eco-friendly and low-cost solvent for the green synthesis of benzene tris-carboxamides. The reactions were carried out via a Passerini approach at 50ºC for relatively shorter reaction times. The antibacterial action of the synthetic tris-carboxamides was investigated, and some of them gave satisfactory and promising antibacterial results. The structures of the resulting molecules were evaluated and confirmed with the help of spectral data and elemental analyses.

کلیدواژه ها

Passerini reaction, antibacterial activity, Trimesic acid

وضعیت: پذیرفته شده