Exploring Enzyme-Mimetic Catalysis with Carbon Quantum Dots for Organic Synthesis

کد مقاله : 1309-ICOC

نویسندگان

مرتضی حسنی *، حمیدرضا کلهر دانشگاه صنعتی شریف

چکیده مقاله

Enzymes are masterpiece of nature in catalysis. During the evolution, they have learned to catalyze their native transformation selectively and economically. As such, there is a great deal of interest in enzyme mimetic catalysis among scientists. Recently, carbon quantum dots (CQDs), spherical and fluorescent carbon nanoparticles with a size range of below 10 nm, have been recognized as promising template in enzyme mimic catalysis. Here, we wish to demonstrated that how bioinspired CQDs, amino acid-enhanced CQDs in particular, could efficiently facilitate challenging organic reactions [1-3]. A hydrothermal bottom-up method was applied to design various CQDs. Different amin acids such as lysine were used to modify the as-synthesized CQDs. We have applied these nanoparticles in intended organic reactions. Of particular interest was condensation reactions with the aim of carbonylation for synthesizing (thio)urea, amide, and formamide compounds. The outperformed nanocatalyst was fully characterized using advanced analytical techniques to gain a detailed understanding of the catalysts features and reaction mechanism. Encouraged by our achievements in this step, we have next shifted our focus to the design of a true example of nanozyme by advanced CQD catalysts. In doing so, a whole-cell or multienzyme mimic nanozyme was designed for the multi-enzymatic metabolism of biomolecules using simply boron-enhanced CQDs, converting amino acid substrates to aldehyde counterparts. In brief, CQDs have showed great potential as catalysts in organic synthesis. Based on unique structural and physicochemical features CQDs are viable candidates for preparing (multi)enzyme mimetic catalysts and nanozymes.

کلیدواژه ها

CQD, Enzyme Mimetic Catalysis, Organic Synthesis, Nanozymes

وضعیت: پذیرفته شده