Heterogeneous nanocatalysts based on metal-organic/polymer frameworks for the synthesis of spiro-acridine

کد مقاله : 1323-ICOC

نویسندگان

samireh rasoolabadi * دانشجو

چکیده مقاله

The synthesis of heterocycles has always been a topic of great interest due to the pharmacological, agricultural, and industrial significance of most heterocyclic structures. Among the wide variety of N-heterocyclic compounds, acridine moieties are notable for their antitumour, antiparasitic, antifungal, antibacterial, and anthelmintic properties. In our research to develop efficient methods for synthesizing heterocycles and preparing nanocatalysts, we report the highly stable and recyclable synthesis and application of heterogeneous nanocatalysts based on metal-organic or polymer frameworks for the synthesis of spiro-acridines. We have developed a novel, efficient, and clean route for the synthesis of a new class of spiro-acridines via an unexpected three-component reaction between dimedone, various anilines, and isatin on a new catalyst. The products were successfully synthesised under the reaction conditions using dimedone, isatin, and anilines at room temperature in aqueous ethanol.

کلیدواژه ها

Heterocycles, Heterogeneous, Nanocatalysts, Metal-organic/polymer frameworks

وضعیت: پذیرفته شده