| Formulation and Evaluation of Physical Stability of Pomegranate Seed Oil Nanoemulsion Based on Nonionic Surfactant |
| کد مقاله : 1328-ICOC |
| نویسندگان |
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مریم منظری توکلی *1، ساجده شجاع2، نسیم نیکجو توابی3، صمد نژاد ابراهیمی3 1عضو هیات علمی سازمان پژوهشهای علمی و صنعتی ایران 2تهران، سازمان پژوهشهای علمی و صنعتی ایران 3دانشگاه شهید بهشتی |
| چکیده مقاله |
| Introduction: Pomegranate seed oil has valuable biological properties but its hydrophobic nature limits use in aqueous systems. This study aimed to develop a stable nanoemulsion using a nonionic surfactant to improve its dispersibility and physical stability. [1]. Materials and Methods: In the preparation of pomegranate seed oil nanoemulsion, the nonionic surfactant Tween 80 was used. The formulation consisted of 5% by weight of oil, 10% by weight of surfactant and 85% distilled water. The preparation process was carried out in two stages: first, the oil and surfactant were mixed for 30 minutes at 600 rpm on a magnetic stirrer to prepare the oil phase. Then, the oil phase was added dropwise to water and mixed using a homogenizer at 14,000 rpm to form the initial emulsion. Finally, particle size reduction was performed using probe sonication for 15 minutes at 80% power and pulse mode (10 seconds on, 5 seconds off) [2]. Results and Discussion: The prepared nanoemulsion had an initial average particle size of about 18.80 nm with a narrow distribution. During the 50-day storage period, the particle size increased to 33.84 nm, indicating acceptable stability of the system. The PDI value remained within the appropriate range and no phase separation was observed in the centrifugation test. The apparent transparency and uniformity of the nanoemulsion were maintained over time [3]. Conclusion: The results show that the use of Tween 80 allows the production of stable pomegranate seed oil nanoemulsions with very small particle sizes and desirable physical stability. This system can be a suitable platform for the application of pomegranate seed oil in aqueous formulations, especially in the food, cosmetic and pharmaceutical industries. |
| کلیدواژه ها |
| Pomegranate seed oil, Nanoemulsion, Tween 80, Physical stability, DLS |
| وضعیت: پذیرفته شده |