Preparation, characterization, and biological study of functionalized Sodium Alginate and Chitosan Composite bearing Zinc Oxide Nanoparticles

کد مقاله : 1331-ICOC

نویسندگان

علیرضا صالحی آذری *، مسلم منصور لکورج دانشگاه مازندران

چکیده مقاله

Sodium Alginate–Chitosan blends are attractive biodegradable matrices for the fabrication of bioactive films; however, their mechanical strength and intrinsic antibacterial properties often require improvement. For this purpose, introducing permanent cationic sites via quaternization is a practical strategy to enhance antimicrobial function and processability in aqueous systems [1]. In parallel, ZnO nanoparticles are widely used as antibacterial fillers [2]. Therefore, in this study, sodium alginate and chitosan were firstly functionalized with 3-chloro-2-hydroxypropyltrimethylammonium chloride to form quaternized derivatives, and then blended them at different quaternized ratios. Sodium dodecyl sulfate was added to improve interpolymer compatibility, polyvinyl alcohol was used as a reinforcing component, and ZnO nanoparticles were incorporated as antibacterial/reinforcing agents (Scheme 1). Films were prepared by solution processing and characterized by FTIR, 1H-NMR, XRD, FE-SEM, DSC, and TGA; mechanical testing and Kirby–Bauer disk diffusion were used to assess performance. Structural analyses confirmed the successful introduction of quaternary ammonium groups and uniform dispersion of ZnO nanoparticles. The final film achieved a tensile strength of 21 MPa, and ZnO increased the thermal degradation temperature by 25–30°C. Antibacterial testing showed a larger inhibition zone against Bacillus subtilis (25mm with ZnO vs 17mm without ZnO), indicating a clear bioactivity enhancement. Overall, the final film is mechanically stronger, thermally more stable, and more antibacterial, suitable for active packaging and biomedical surface applications.

کلیدواژه ها

Quaternized Chitosan, Quaternized Sodium Alginate, Zinc Oxide nanoparticles, Antibacterial films

وضعیت: پذیرفته شده